pentobarbital will decrease the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.pentobarbital will decrease the level or effect of doxorubicin liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Sodium valproate and valproic acid surf